Uncertainties are an inherent part of doing business and are dealt with relatively high degree of confidence. Uncertainties pose a variety of risks that can even pull down the organizations. This study has determined the impact of the general uncertainties and its possible minimization. Uncertainties are quite ambiguous for e.g. political upheavals, natural disasters, which cannot be predicted and create impulsive fall-outs for the supply chain process for any business. However, results found that organizations face major disruptions in supply chain operations when uncertainties are caused and it mainly damages the overall revenue score of the product/service, if the organization has no contingency planning system.